This ad from Dell popped into our mailbox this morning. Hmm. Something about that equation seems familiar. Wikipedia?
This equation was used in the development of the atomic bomb. By measuring the mass of different atomic nuclei and subtracting from that number the total mass of the protons and neutrons as they would weigh separately, one could obtain an estimate of the binding energy available within an atomic nucleus. This could be and was used in estimating the energy released in the nuclear reaction, by comparing the binding energy of the nuclei that enter and exit the reaction.