You're forgiven if you don't know there's a company a few miles north of Google that pulls in more than $10 billion a year selling drugs. Genentech makes the cancer treatment Avastin, the arthritis and lymphoma drug Rituxan, and the breast cancer fighter Herceptin, each of which bring in a few billion a year. Its stock, which trades under the symbol DNA , nearly touched $100 a share yesterday, a three-year high. Market cap is just over $100 billion, not far behind Google's $118 billion. Once you know all that, it's not surprising that the company nixed a buyout offer from Roche, its majority shareholder. San Francisco's bid to become the world's biotech center is moving more slowly than planned , but just you wait another ten years. These little drug companies are going to get a lot bigger.