No. 2 – Tom & Lynette, Desperate Housewives: She has him canned from her ad firm, hates mothering and almost cheats on him with a pizza guy. He, in turn, takes it like a tool as penance for lying about his secret kid. Forget Wisteria Lane’s occasional homicides, the real mystery here is why these two aren’t in therapy. No. 1 – “Gizzie” (George & Izzie), Grey’s Anatomy: First off, could the combo name be any uglier? And secondly, ewww. It was like watching a faded prom queen and her slightly dim-witted brother get it on…at the expense of George’s marriage to Callie.While we're a little shocked that Boris & Natasha made the list over, say, Hills villains Heidi & Spencer, we can't help but wish TV Guide had extended its expose to include characters from decades long since past. After all, everyone knows that Shirley and the Big Ragu were, like, sooo passé (all the cool kids 'shipped Laverne and Squiggy), and Donna's marriage on The Donna Reed Show? OMG, could she have been more of a Mary Sue?!