Can you destroy — or cement — your professional reputation in 140 characters or less? On Twitter, it's easy! Watch and learn from ABC's Jake Tapper, ex-Wonkette Ana Marie Cox, VentureBeat's Eric Eldon and others:

TechPresident's Micah Sifry leaked Obama Web guru Katie Stanton's complaint about government bureaucracy.

Boing Boing adventuress continued her travels in Africa.

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Jake Tapper, ABC's resident hunk of red hot newsmeat, gave an incomprehensible update about President Obama's quest for culinary knowledge.

VentureBeat blogger Eric Eldon exemplified the South By Southwest work ethic.

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As did Air America radio hostess and frequent alcohol seeker Ana Marie Cox.