Janklow started out as an aspiring rock star, fronting the band Darlahood, which toured during the '90s supporting the likes of Helmet. (Darlahood's sound was once described as "the return of a riff-heavy, self-indulgent, guitar-fueled brand of 'head' music that went out of style with strawberry rolling papers.") The 6-foot, 6-inch Janklow threw in the towel at age 30 and joined literary agency Janklow & Nesbit in 1999. He's not the "Janklow" on the letterhead, though—that's his father, Mort Janklow, who co-founded the firm with Lynn Nesbit.
Luke represents the likes of Anderson Cooper, American Idol's Simon Cowell, and Atoosa Rubenstein. (Other names Janklow & Nesbit represents: Malcolm Gladwell, Bill O'Reilly, Barbara Walters, and Michael Moore.) But the attention-seeking Janklow has also managed to earn some notoriety outside the publishing biz: He was featured in Men's Vogue and in 2004 appeared with his wife in an ad campaign for TSE cashmere. In 2007 he was named the "hottest straight man in publishing" by Gawker.com.
In early 2009, it was reported that Luke was divorcing his wife, Julie, a former singer and musician, and with whom he has a son named August. (Just months before the couple split up, the couple had opened a West Village restaurant, Sweetiepie, with Mario Batali.) Janklow later dated model/writer Jessica Joffe.
At a book party he threw for Tom Sykes in 2006, Janklow made all the assembled guests put booties over their shoes so as to not dirty his marble staircase.