After seeing the film Dr. No, Joseph Barbera decided he needed to make a high-tech adventure cartoon, and so Jonny Quest was born. There have been three variations of the show since it's inception, but the parodies spawned are uncountable.
Jonny Quest: The Mystery of the Lizard Men
The New Adventures of Jonny Quest: The Monolith Man
The Real Adventures of Jonny Quest: The Realm of the Condor
The show The Venture Brothers itself is a parody of Jonny Quest, but the Quest characters actually show up on the program, for instance here when an older Jonny makes one hell of an insult:
And remember the cartoon Freakazoid? A segment called "Toby Danger" was the most spot on parody of the franchise to ever be released: