I'm 160 hours in and can't continue the main quest because of a bug that won't let me start the "Cornered Rat" quest. I'm a little pissed off about that and some other bugs that seriously affect my overall enjoyment of this game. The lag was a minor pain compared to having to start from scratch because of the bugs in the quests. In no way could I vote this game of the year as much as I've enjoyed it up top this point.
I have seen much more hilarious stuff personally. The one that sticks out the most is when we put up a full screen promoting a "breakfast with Santa" around Christmas. But the dude making the graphics wrote "Breakfast with Satan" instead. And yes, it made air.