The square-jawed co-host of Fox News' The Five, Guilfoyle is the former wife of both San Francisco mayor Gavin Newsome and furniture heir Eric Villency.
Born to a Puerto Rican mom and Irish construction worker dad, Guilfoyle was born and raised in San Francisco and worked as an underwear model during college at UC Davis. She traded up to catalog modeling while attending law school at the University of San Francisco, and worked as an assistant district attorney in San Francisco after graduating. When a new DA was elected in 1996, he sent Guilfoyle packing, and she lived in LA for four years before returning to the DA's office in San Francisco in 2000. The high-profile dog mauling death of Bay Area resident Diane Whipple in 2001 first landed Guilfoyle in the spotlight, and she became even more prominent when she started dating Gavin Newsom, the ambitious city supervisor who was preparing a bid for mayor. After he was elected in 2003, Guilfoyle became the city's First Lady, but the marriage soon crumbled, at which point she moved to New York and joined Court TV as co-host of Both Sides. In January 2006, Guilfoyle found a home at Fox News as the host of the one-hour crime program The Line Up. Although the show was eventually canceled, she is still a Fox News regular, popping up as one of the rotating co-hosts on the Glenn Beck replacement The Five and as a contributor for Red Eye and The O'Reilly Factor.